Inhibitory effects of calcium or magnesium ions on PDI
نویسندگان
چکیده
Photodynamic inactivation of microorganisms (PDI) finds use in a variety applications. Several studies report on substances enhancing or inhibiting PDI. In this study, we analyzed the inhibitory potential ubiquitous salts like CaCl2 and MgCl2 PDI against Staphylococcus aureus Pseudomonas aeruginosa cells using five cationic photosensitizers methylene blue, TMPyP, SAPYR, FLASH-02a FLASH-06a. TMPyP changed its molecular structure when exposed to MgCl2, most likely due complexation. substantially affected singlet oxygen generation by MB at small concentrations. Elevated concentrations impaired up total loss bacterial reduction, whereas is more detrimental for than MgCl2. Binding assays cannot not explain differences efficacy. It assumed that divalent ions tightly bind hindering close binding membranes. Consequently, photosensitizer might be shifted outer compartments teichoic acids Gram-positives sugar moieties LPS Gram-negatives, attenuating oxidative damage susceptible cellular structures. conclusion, have an different phases These effects should considered environment contains such tap water fields food industry.
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ژورنال
عنوان ژورنال: Journal of photochemistry and photobiology
سال: 2022
ISSN: ['2666-4690']
DOI: https://doi.org/10.1016/j.jpap.2022.100122